Effectively addressing HIV, HCV, and STBBIs among Indigenous people requires the adoption of a human rights approach, focusing on evidence-based and culturally sensitive interventions that embrace Indigenous ways of knowing and doing. In addition to the legal and policy recommendations described below, it is imperative moving forward that access to emerging health care technologies and new testing and treatment options be made truly equitable. The knowledge and benefits of scientific research and development (e.g. pre-exposure prophylaxis [PrEP], long-acting injectables, multiplex testing, self-testing, etc.) must be shared with all, so that Indigenous communities can achieve equitable outcomes in realizing the right to health.